The proof is in the pet.

GlycoFlex® was used in a randomized, double-blind, cross over design dog study at Washington State University. In this study, researchers used an osteoarthritis (OA) model to determine if GlycoFlex® could support normal joint function in affected patients.

The results of the study suggest that GlycoFlex® may help normalize joint function in dogs with joints affected by OA.

PEAK VERTICAL FORCE

SYNOVIAL PGE² CONCENTRATION

Composure™ was used in a blind, repeated measures study with two treatment groups conducted by CanCog Technologies to demonstrate that a single dose of Composure™ would have anxiety reducing properties in dogs, with specific objectives of establishing the onset and duration of anxiolytic properties of Composure™.

The group taking Composure™ showed more thunder-phobic activity at baseline than at either 30 minutes or 4 hours after administration. By contrast, the placebo group did not differ in activity at 30 minutes or 4 hours. This suggests a calming effect in the Composure™ group not seen in the placebo group.

LOCOMOTOR ACTIVITY

Composure™ Long Lasting was used in a blinded, repeated measures study with two experimental groups conducted by CanCog Technologies. The study was designed to demonstrate that a single dose of Composure™ Long Lasting would have calming properties in dogs, with specific objectives of establishing the onset and duration of calming properties of Composure™ Long Lasting. Testing took place before, during and after dogs were exposed to a thunderstorm audio recording.

At 8 hours post dosing, the group taking Composure™ Long Lasting showed a statistically significant affect on heart rate both before and during thunder compared to baseline. By contrast, the group taking a generic calming chew had significantly higher heart rates before and during thunder compared to baseline. The group taking Composure™ Long Lasting also exhibited significantly fewer head movements during thunder while the generic group had more head movement. The Composure™ Long Lasting group also exhibited significantly lower before thunder global anxiety scores vs. the generic group with higher scores. Pre-thunder anxiety intensity was significantly lower in the Composure™ Long Lasting group compared to the generic group.

These results also determined there was a significantly positive (increasing) relationship of pre, during and post thunder heart rates, global anxiety scores, and anxiety intensity over time, suggesting the dogs exhibited conditioned anxiousness related to repeated exposure to the thunderstorm audio. However, the Composure™ Long Lasting group still exhibited significantly greater calming properties at 8 hours after dosing compared to the generic group. This suggests that Composure™ Long Lasting exhibits an effect on both conditioned and acute calming properties that was not demonstrated in the generic group.

AVERAGE CHANGE IN BEHAVIORAL VARIABLES AT 8 HOURS

Perio Support powder was evaluated using double-blinded trial protocol. A total of 20 canine (Greyhound) subjects’ teeth were evaluated. Study subjects in each test group were offered the assigned control or test product twice daily during a scheduled meal feeding. Prior to the study each animal had his/her teeth cleaned, scaled and polished after which the presence of gingivitis, calculus and plaque was assessed. Evaluation of plaque, gingivitis, and calculus was completed on each animal 14 and 28 days after the initial assessment. The examination of teeth included the buccal surfaces and both sides of the mouth. Review was limited to the following 7 teeth: Maxillary Canine, Maxillary 3rd Premolar, Maxillary 4th Premolar, Mandibular Canine, Mandibular 3rd Premolar, Mandibular 4th Premolar, Mandibular 1st Molar. Experienced dental hygienists performed the scaling and scoring of the teeth. Specific criteria for evaluation are those set forth by VOHC (Veterinary Oral Health Council).

Administering Perio Support powder to the dog’s food twice daily at the recommended amount resulted in a significant decrease in plaque formation as well as a strong trend in the decrease of calculus formation. Results demonstrate the reduction in overall plaque by 20% and calculus by 18% in the 28-day trial when compared with the control subjects.