Free Shipping on Orders $35+

Due to a high number of holiday orders, we are temporarily pausing the ability to place new orders on We're currently working to get all of the orders that have been placed out the door as quickly as we can. We'll begin accepting new orders again soon. You can still purchase products from many of our retail partners. See more details here.

The GlycoFlex® Difference

GlycoFlex® is Clinically Proven Joint Support for Pets

1 in 5 dogs have joint issuesAs many as 20% of dogs in North America over the age of one suffer from joint problems, according to a 2020 study.1 While many pet parents may think that joint discomfort is only a concern for senior dogs and cats, joint inflammation and degeneration associated with aging can start much earlier than you may think.

Adding a quality joint support supplement to your pet’s diet can not only support mobility and strength, it may help with joint discomfort associated with aging.

GlycoFlex® Plus combines glucosamine, chondroitin, green-lipped mussel, DMG, MSM, and important antioxidants to support your pet’s mobility and comfort. It’s an advanced joint support supplement for dogs and cats of any age.


Source: Washington State University Study: "The effects of GlycoFlex® 3 on stable stifle osteoarthritis model in dogs"

In a clinical study, dogs receiving GlycoFlex® 3 showed a 41% increase in hind-leg strength after four weeks of treatment, 2 compared to pretreatment values. GlycoFlex® is a powerful, popular choice among pet owners due to the combination of effective, clinically proven ingredients. 

More Than Just Joint Support

Our proprietary GlycoFlex® supplements feature quality ingredients that combine to offer multiple benefits beyond just advanced joint support!


Support health for brain, skin, heart, and eyes


Free-radical fighters that provide cellular protection


Building blocks for the whole body, and support skin, bones, cartilage, glands, and organs

GlycoFlex® Features Proven, Effective Ingredients

effective ingredients of GlycoFlexeffective ingredients of GlycoFlex

Perna canaliculus, otherwise known as green-lipped mussel, is the foundation of our formula and nature’s perfect blend for joint support. This New Zealand mussel is a whole-food organism, and a natural source of chondroitin and glucosamine as well as antioxidants and omega-3 fatty acids. We’ve been trusting it for our pets for over 40 years.

N,N-Dimethylglycine (DMG) supports your pet’s overall comfort and performance by supporting circulation, efficient oxygen utilization, and energy.

A natural component of your pet’s connective tissue, chondroitin sulfates help support the structure and integrity of those tissues to promote joint flexibility and overall mobility.

Glucosamine, like chondroitin, is a critical nutrient for building healthy connective tissue, and is one of the foundational compounds in cartilage.

Methylsulfonylmethane (MSM) is a sulfur compound found naturally in your pet’s body. As an important addition to our GlycoFlex® formula, it supports many bodily processes, including collagen synthesis.

Vitamins C and E, and other nutrients like manganese, selenium, and grape seed extract, play a critical supporting role in helping glucosamine and chondroitin do their job effectively.

These ingredients are all found in GlycoFlex® Plus, an advanced joint support supplement for dogs of any age, as well as in other formulas in our veterinarian-approved GlycoFlex® joint support line. See which product would be best suited for your pet and their unique needs. 

Take the Quiz

The Power of Perna

Perna canaliculus is rich in a number of helpful substances like amino acids, minerals, fatty acids, vitamins, and glycoproteins. Overall, it provides 57 nutritional factors needed for joint comfort, mobility, and repair. 

green-lipped musclesgreen-lipped muscles

Key nutrients include:

  • Natural Glucosamine: A key building block for healthy cartilage
  • Chondroitin Sulfates: The principal component of cartilage, the shock absorbers for joints
  • Hyaluronic Acid: Necessary for maintaining the proper consistency of synovial fluid surrounding the joint
  • Essential Fatty Acids: A natural anti-inflammatory which is not produced by the body
  • Amino Acids: The building blocks of all bodily tissue - green-lipped mussel contains 21 different amino acids
  • Minerals: Important cofactors for bone and cartilage health 

Compare GlycoFlex® Joint Supplements for Dogs

  GlycoFlex 2 joint support GlycoFlex 3 joint support GlycoFlex Plus joint support





Active pets

in need of

additional joint


Advanced joint

support for

senior dogs

Ultimate joint

support, mobility

and comfort for

all dogs

Active Ingredients Per 2 Chews Per 2 Chews Per 2 Chews
Glucosamine 750 MG 1000 MG 1000 MG
MSM 500 MG 1000 MG 1000 MG
Condroitin - - 400 MG
Perna (Green-Lipped Mussel) 600 MG 600 MG 600 MG
DMG 100 MG 100 MG 100 MG
Vitamin E - 50 IU 50 IU
Vitamin C - 24 MG 24 MG
Manganese 10 MG 10 MG 10 MG
Grape Seed Extract - 5 MG 5 MG
L-Glutathione - 2 MG 2 MG
Selenium - 0.002 MG 0.002 MG
GlycoFlex supplement ingredientsGlycoFlex supplement ingredients

Which GlycoFlex® is Right for My Pet?

1 Risk Factors for Canine Osteoarthritis and Its Predisposing Arthropathies: A Systematic Review 
2 Washington State University Study: "The effects of GlycoFlex® 3 on stable stifle osteoarthritis model in dogs"

Stay in the Know!

Subscribe to our email list for exclusive news, tips, and special offers:

Follow us on Social Media

Facebook   Instagram   TikTok   Pinterest   YouTube